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The Urotensin II System in Ischaemic Myocardial Dysfunction.

REA Auditado

Urotensin II (UII) was first isolated from the marine Goby fish and subsequently found active in the mammalian cardiovascular system. UII interaction with its receptor UT is pseudo-irreversible suggesting that alterations in UT expression may be an important determinant of functionality. More recently UII has been implicated in diseases such as diabetes, renal dysfunction and in particular heart failure. Indeed there is evidence of upregulation of UII and possibly UT in heart failure.
Data from 40 elective coronary artery bypass surgery patients are presented.

Tema: general: 

• General

Characterisation and Mechanism of Bone Marrow Cell-Induced Myocardial Protection

REA Auditado

It is controversial whether the administration of bone marrow cells (BMCs) can repair
the heart after an ischaemic insult and whether the mechanism of the putative beneficial
effect is due to a paracrine action. By using an experimental model of simulated
ischaemia of the atrial myocardium, I set up this thesis to understand the protective
properties of BMCs on the human myocardium with different clinical conditions and to
investigate the underlying mechanism.

Tema: general: 

• General

Ischaemic Preconditioning of the Human Heart: Mechanisms of Myocardial Protection

REA Auditado

Ischaemic preconditioning (PC) describes the increased resistance to myocardial infarction that follows short sublethal periods of ischaemia. It has been shown to exist in all mammalian species investigated to date. In the early 90's, some evidence started to evolve which reported that this powerful cardioprotective phenomenon exists in man. After ischaemia that triggers preconditioning, there are 2 phases of protection: an early phase (short-lived) termed early of classic preconditioning and a late (more prolonged) phase termed a second window of protection.

Tema: general: 

• General