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Metabolismo energético del corazón y sus proyecciones en el tratamiento de la insuficiencia cardíaca

REA Auditado

It is unknown why heart failure progresses even when patients are treated with the best therapy available. Evidences suggest that heart failure progression is due to loss of neurohumoral blockade in advanced stages of the disease and to alterations in myocardial metabolism induced, in part, by this neurohumoral activation. Alterations in cardiac energy metabolism, especially those related to substrate utilization and insulin resistance, reduce the efficiency of energy production, causing a heart energy reserve deficit. These events play a basic role in heart failure progression.

Tema: general: 

• Ciencias de la Salud›Medicina›Medicina (en General)

Tuberculosis: una dinámica continua entre el pasado y el presente, para imaginar el futuro

REA Auditado

Progress in understanding the biological processes that allow Mycobacterium tuberculosis to be a successful parasite have accelerated in the last twenty years. This progress has been stimulated by the return of tuberculosis (TB) as an important disease in industrialized countries, by its increase in emergent nations in the tail of population increases and poverty and by the spread of multiple drug resistant (MDR) and extensively drug resistant (XDR) M. tuberculosis as a result of treatment failures. Progress on M.

Tema: general: 

• Ciencias de la Salud›Medicina›Medicina (en General)

Study of the action of tamoxifen on the mammary gland epithelium of premenopausal patients by lysosome quantification

REA Auditado

Tamoxifen is an antiestrogen drug widely utilized for the adjuvant hormonal treatment of breast carcinoma. Its use in the primary prophylaxis of this disease is currently being proposed. Although the drug has few side effects, its precise action on breast tissue that has not undergone neoplastic transformation has not been fully elucidated.

Tema: general: 

• Ciencias de la Salud›Dieta y Nutrición Clínica

Alergia a beta-lactámicos

REA Auditado

Betalactams allergy is the first cause of drug allergy in the world. In Chile cutaneous test are performed without considering international standardizations. This review focuses in betalactam allergy diagnosis and its management. Betalactams allergic reactions can be classified according to their temporal profile, into immediate, accelerated or late reactions which coincides with symptoms and pathogenic mechanisms. Most of immediate and accelerated reactions are mediated by specific IgE, with symptoms of immediate hypersensitivity.

Tema: general: 

• Ciencias de la Salud›Medicina›Medicina Interna

Consumo de antidepresivos en Chile entre 1992 y 2004

REA Auditado

Background: Data from the Ministry ofHealth show that in Chile in 2004, 17% of the population had some form of depression and mood disorders are the tenth cause of disability-adjusted Ufe years (DALY) loss. Aim: To determine consumption of antidepressants (ADs) in Chile from 1992 to 2004.

Tema: general: 

• Ciencias de la Salud›Medicina›Medicina (en General)

Upper extremity nerve lesions (diagnosis, indications, surgical techniques)

REA Auditado

OBJECTIVE: Revision and questioning of orthodox principles regarding the conduction of nerve impulse. DESIGN: Retrospective study with clinical analysis of results. SITE: Hospital das Clinicas (HCFMSP), public university institution with research programs and tertiary attention to health. GROUP MEMBERS: Author and a team of residents and trainees. OPERATION: Direct suture of nervous stumps utilizing auxiliary technical procedures:- joint-flexion, nerve transposition, tendon transplants, bone shortening.

Tema: general: 

• Ciencias de la Salud›Dieta y Nutrición Clínica