In his new book, The Creative Destruction of Medicine: How the Digital Revolution Will Create Better Health Care, Eric Topol argues that medicine is set to undergo its biggest shakeup in history, pushed by demanding consumers and the availability of game-changing technology. Topol -- a cardiologist, director of the Scripps Translational Science Institute and co-founder of the West Wireless Health Institute in La Jolla, Calif. -- was recently interviewed for Knowledge@Wharton by C. William Hanson, III, director, surgical intensive care, at the Hospital of the University of Pennsylvania.