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Increased p53 gene dosage reduces neointimal thickening induced by mechanical injury but has no effect on native atherosclerosis

REA Auditado

OBJECTIVE: The tumor suppressor p53 regulates cell proliferation and apoptosis, two key processes in the pathogenesis of occlusive vascular disease. Here, we examined the consequences of heightening p53 function on neointimal lesion formation in the setting of atherosclerosis and
mechanical injury.

Tema: general: 

• Ciencias de la Salud

Bifidobacteria inhibit the inflammatory response induced by gliadins in intestinal epithelial cells via modifications of toxic peptide generation during digestion

REA Auditado

Celiac disease (CD) is a chronic enteropathy triggered by intake of gliadin, the toxic component of gluten. This study aims at evaluating the capacity of different Bifidobacterium strains to counteract the inflammatory effects of gliadin-derived peptides in intestinal epithelial (Caco-2) cells. A commercial extract of several gliadin (Gld) types (α,β,γ,ω) was subjected to in vitro gastrointestinal digestion (pepsin at pH 3, pancreatin-bile at pH 6), inoculated or not with cell suspensions (108 colony forming units/ml) of either B. animalis IATA-A2, B. longum IATA-ES1, or B.

Tema: general: 

• Ciencias›Química

Human Impact Since Medieval Times and Recent Ecological Restorationin a Mediterranean Lake: The Laguna Zoñar, Southern Spain

REA Auditado

The multidisciplinary study of sediment cores from Laguna Zoñar (37°29′00′′ N, 4°41′22′′ W, 300 m a.s.l., Andalucía, Spain) provides a detailed record of environmental, climatic and anthropogenic changes in a Mediterranean watershed since Medieval times, and an opportunity to evaluate the lake restoration policies during the last decades. The paleohydrological reconstructions show fluctuating lake levels since the end of the Medieval Warm Period (ca.

Tema: general: 

• Ciencias

La restauración de la iglesia visigoda de Santa Lucía del Trampal. Alcuescar (Cáceres)

REA Auditado

[ES] La restauración de la iglesia visigoda de Santa Lucía del Trampal ha constituido una experiencia sumamente interesante como proyecto integrado de restauración e investigación histórica y arqueológica. Tal carácter ha condicionado de forma especial, no sólo la metodología, sino también los criterios y por tanto los resultados.

Tema: general: 

• Historia y Arqueología›Regiones y Países›Asia y Oriente Medio›Países Árabes e Islámicos (General)

Field and experimental studies on Dicrocoelium dendriticum and dicrocoeliasis in northern Spain.

REA Auditado

The transmission, control and the relationship between Dicrocoelium dendriticum and its definitive (sheep and cattle) and intermediate (molluscs and ants) hosts under natural and experimental conditions are described. Eleven species of molluscs and four of ants were found infected with larval D. dendriticum in León province, north-west Spain. Infected ants were observed between April and November and in tetania at 7.5-26.9 degrees C. The highest shedding of eggs by sheep and cattle was detected in winter. Two treatments applied in November and January were the most effective.

Tema: general: 

• Ciencias›Agricultura y Zoología

Natural infection of Lymnaea truncatula by the liver fluke Fasciola hepatica in the Porma Basin, León, NW Spain.

REA Auditado

For two years fortnightly malacological samplings were carried out to collect Lymnaea truncatula (Mollusca; Basommatophora) at five points in the upper and middle Porma river basin, León, Spain. The highest numbers of snails were collected in September, May and November. Of the 5486 molluscs examined, 11.41% harboured F. hepatica (Trematoda; Digenea) with an average intensity of 20.14. In general, the values of both infection prevalence and intensity increased with the size of the snails.

Tema: general: 

• Ciencias›Agricultura y Zoología

Structural aspects of binding of alpha-linked digalactosides to human galectin-1

REA Auditado

By definition, adhesion/growth-regulatory galectins are known for their ability to bind beta-galactosides such as Gal beta(1 -> 4)Glc (lactose). Indications for affinity of human galectin-1 to alpha-linked digalactosides pose questions on the interaction profile with such bound ligands and selection of the galactose moiety for CH-pi stacking.

Tema: general: 

• Ciencias›Biología

Molecular reorganization of endocannabinoid signalling in Alzheimer’s disease

REA Auditado

Retrograde messengers adjust the precise timing of neurotransmitter release from the presynapse, thus modulating synaptic efficacy and neuronal activity. 2-Arachidonoyl glycerol, an endocannabinoid, is one such messenger produced in the postsynapse that inhibits neurotransmitter release upon activating presynaptic CB1 cannabinoid receptors. Cognitive decline in Alzheimer’s disease is due to synaptic failure in hippocampal neuronal networks. We hypothesized that errant retrograde 2-arachidonoyl glycerol signalling impairs synaptic neurotransmission in Alzheimer’s disease.

Tema: general: 

• Ciencias de la Salud›Medicina›Neurología

Cortical interneurons: from Cajal to 2001

REA Auditado

After the collective work of many investigators, beginning with the early studies of Cajal, the following main conclusions may be drawn regarding the morphology, biochemical characteristics and synaptic connections of interneurons: 1. Interneurons show a great variety of morphological, biochemical and physiological types. They constitute approximately 15-30% of the total population of neurons. 2.

Tema: general: 

• Ciencias de la Salud›Medicina›Neurología

3D Gravity Inversion by Growing Bodies and Shaping Layers at Mt. Vesuvius (Southern Italy)

REA Auditado

To improve our knowledge of the structural pattern of Mt. Vesuvius and its magmatic system, which represents one of the three volcanoes located in the Neapolitan area (together with Campi Flegrei and Ischia; southern Italy), we analyze here the Bouguer gravity map that is already available through its interpretation by means of 2.5-dimensional modelling. We have carried out a three-dimensional interpretation using a new and original algorithm, known as ‘Layers’, that has been especially processed for this purpose.

Tema: general: 

• Ciencias›Astronomía y Astrofísica